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Eaton’s Reagent: A Less Viscous Alternative to PPA

Eaton’s reagent (1, phosphorus pentoxide - methanesulfonic acid solution in the ratio of 1:10 by weight) is used as an alternative to polyphosphoric acid (PPA) in organic synthesis. In addition its ease of handling, yields obtained with the Eaton’s are better than those obtained with PPA. Recently, the efficient cycloacylation of aniline derivatives to 4-quinolones, investigated as antibiotics, etc., was reported.1)


  • 1)A Mild and Efficient Synthesis of 4-Quinolones and Quinolone Heterocycles
  • 2)Seminal Publication
  • 3)Reviews
    • a)S. C. Virgil, in Encyclopedia of Reagents for Organic Synthesis, ed. by L. A. Paquette, John Wiley & Sons, Chichester 2001, pp. 4129-4132.
    • b)Fieser and Fiesers’ Reagents for Organic Synthesis, John Wiley & Sons, Vol. 5, p. 535; Vol. 7, pp. 291-292; Vol. 8, pp. 400-401; Vol. 11, p. 428.
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