CAS RN: 141430-65-1 | Product Number: A3169
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|Purity / Analysis Method||>98.0%(HPLC)|
|Molecular Formula / Molecular Weight||C__1__8H__1__7N__3O__4S = 371.41|
|Physical State (20 deg.C)||Solid|
|Condition to Avoid||Heat Sensitive|
|Reaxys Registry Number||5455834|
|PubChem Substance ID||354335530|
|Appearance||White to Yellow to Orange powder to crystal|
|Purity(HPLC)||min. 98.0 area%|
|Elemental analysis(Nitrogen)||10.70 to 11.90 %|
|Melting Point||162 °C(dec.)|
ABT-751 (E71) is a sulfonamide tubulin polymerization inhibitor, which is active against tumor cells. ABT-751 binds to the colchicine site on β-tubulin, and inhibits polymerization of microtubules that leads to a block in the cell cycle at the G2M phase, resulting in cellular apoptosis. (The product is for research purpose only.)
In vivo tumor growth inhibition produced by a novel sulfonamide, E7010, against rodent and human tumors
Mechanism of action of E7010, an orally active sulfonamide antitumor agent: inhibition of mitosis by binding to the colchicine site of tubulin
Variations in the colchicine-binding domain provide insight into the structural switch of tubulin
E7010: investigational anticancer agents targeting the microtubules (a review)
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