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CAS RN: 141430-65-1 | Product Number: A3169


Purity: >98.0%(HPLC)
  • N-[2-[(4-Hydroxyphenyl)amino]pyridin-3-yl]-4-methoxybenzenesulfonamide
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Product Number A3169
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__1__8H__1__7N__3O__4S = 371.41  
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Condition to Avoid Heat Sensitive
CAS RN 141430-65-1
Reaxys Registry Number 5455834
PubChem Substance ID 354335530
MDL Number


Appearance White to Yellow to Orange powder to crystal
Purity(HPLC) min. 98.0 area%
Elemental analysis(Nitrogen) 10.70 to 11.90 %
Properties (reference)
Melting Point 162 °C(dec.)
Related Laws:
RTECS# DB2734000
Transport Information:
HS Number 2935.90.9500
ABT-751 (E7010): A Sulfonamide Tubulin Polymerization Inhibitor

ABT-751 (E71) is a sulfonamide tubulin polymerization inhibitor, which is active against tumor cells. ABT-751 binds to the colchicine site on β-tubulin, and inhibits polymerization of microtubules that leads to a block in the cell cycle at the G2M phase, resulting in cellular apoptosis. (The product is for research purpose only.)


In vivo tumor growth inhibition produced by a novel sulfonamide, E7010, against rodent and human tumors

N. Koyanagi, T. Nagasu, F. Fujita, T. Watanabe, K. Tsukahara, Y. Funahashi, M. Fujita, T. Taguchi, H. Yoshino, K. Kitoh, Cancer Res. 1994, 54, 1702.

Mechanism of action of E7010, an orally active sulfonamide antitumor agent: inhibition of mitosis by binding to the colchicine site of tubulin

K. Yoshimatsu, A. Yamaguchi, H. Yoshino, N. Koyanagi, K. Kitoh, Cancer Res. 1997, 57, 3208.

Variations in the colchicine-binding domain provide insight into the structural switch of tubulin

A. Dorléans, B. Gigant, R. B. G. Ravelli, P. Mailliet, V. Mikol, M. Knossow, Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 13775.

E7010: investigational anticancer agents targeting the microtubules (a review)

K. L. Manasa, Int. J. Pharm. Sci. Res. 2015, 6, 3713.

PubMed Literature

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