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CAS RN: 177036-94-1 | Product Number: A2966

Ambrisentan


Purity: >98.0%(HPLC)
Synonyms:
  • (S)-2-[(4,6-Dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropionic Acid
Documents:
20MG
$22.00
6   Contact Us 19  
100MG
$66.00
2   Contact Us ≥20 

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Product Number A2966
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__2__2H__2__2N__2O__4 = 378.43  
Physical State (20 deg.C) Solid
CAS RN 177036-94-1
PubChem Substance ID 354333648
Merck Index (14) 384
MDL Number

MFCD09842330

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Elemental analysis(Nitrogen) 7.00 to 7.80 %
Specific rotation [a]20/D +170 to +176 deg(C=0.5, MeOH)
Properties (reference)
Melting Point 178 °C(dec.)
Specific Rotation 173° (C=0.5,MeOH)
Solubility in water Insoluble
Solubility (very soluble in) Methanol
Solubility (soluble in) Ethanol,Acetone
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H361 : Suspected of damaging fertility or the unborn child.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P405 : Store locked up.
Related Laws:
RTECS# UA2459660
Transport Information:
HS Number 2933.59.8000
Application
Ambrisentan: A Selective ETA Receptor Antagonist

Endothelin-1 (ET-1) is a peptide that constricts pulmonary blood vessels and raise blood pressure. Two ET-1 receptor subtypes, ETA and ETB, mediate the effects of ET-1 in the vascular smooth muscle and endothelium. The actions of ETA would be vasoconstriction and cell proliferation, while the actions of ETB would be vasodilatation, antiproliferation, and ET-1 clearance. Ambrisentan is a highly selective ETA receptor antagonist with >4000-fold higher selectivity over the ETB receptor. Pulmonary arterial hypertension (PAH) would be derived from the action of ETA receptor. Therefore, ambrisentan is used for the treatment of PAH. (The product is for research purpose only.)

References


PubMed Literature


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