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CAS RN: 54301-15-4 | Product Number: A2777

Amsacrine Hydrochloride


Purity: >98.0%(HPLC)
Synonyms:
  • 4-(9-Acridinylamino)-N-(methanesulfonyl)-m-anisidine Hydrochloride
  • m-AMSA
Documents:
20MG
$131.00
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100MG
$392.00
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Product Number A2777
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__2__1H__1__9N__3O__3S·HCl = 429.92  
Physical State (20 deg.C) Solid
Condition to Avoid Light Sensitive
CAS RN 54301-15-4
Related CAS RN 51264-14-3
Reaxys Registry Number 5692112
PubChem Substance ID 354333613
MDL Number

MFCD07799963

Specifications
Appearance Light yellow to Amber to Dark green powder to crystal
Purity(HPLC) min. 98.0 area%
Elemental analysis(Nitrogen) 9.20 to 10.20 %
Properties (reference)
Melting Point 288 °C
GHS
Pictogram Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H301 : Toxic if swallowed.
H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
H351 : Suspected of causing cancer.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P270 : Do not eat, drink or smoke when using this product.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P302 + P352 : IF ON SKIN: Wash with plenty of soap and water.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
P362 : Take off contaminated clothing and wash before reuse.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P405 : Store locked up.
Related Laws:
RTECS# PB1081000
Transport Information:
UN Number (DOT-AIR) UN2811
Class (DOT-AIR) 6.1
Packing Group (TCI-A) III
HS Number 2933.99.8290
Application
Amsacrine: A DNA Intercalator with the Inhibition of Topoisomerase II

Amsacrine (known as m-AMSA) hydrochloride is an acridine derivative that has a potent antitumor activity against leukemic cells. Amsacrine inhibits topoisomerase II which is a group of essential enzymes for DNA replication with important functions for DNA function and cell survival. Topoisomerase II is now viewed as an important cellular target of antitumor drugs including both DNA intercalators (amsacrine and doxorubicin [D4193]) and the nonintercalator epipodophyllotoxin derivatives (etoposide [E0675] and teniposide [T3109]). Amsacrine is often used in combination with other chemotherapy drugs to treat types of adult leukemia, particularly acute myeloid leukemia (AML). (The product is for research purpose only.)

References


PubMed Literature


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