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CAS RN: 22059-22-9 | Product Number: A2646


Purity: >97.0%(GC)(T)
  • Acetamide Oxime
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Product Number A2646
Purity / Analysis Method >97.0%(GC)(T)
Molecular Formula / Molecular Weight C__2H__6N__2O = 74.08  
Physical State (20 deg.C) Solid
CAS RN 22059-22-9
Reaxys Registry Number 8829065
PubChem Substance ID 253660036
MDL Number


Appearance White to Almost white powder to crystal
Purity(GC) min. 97.0 %
Purity(Nonaqueous Titration) min. 97.0 %
Properties (reference)
Melting Point 138 °C
Solubility (soluble in) Methanol
Pictogram Pictogram
Signal Word Warning
Hazard Statements H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled.
H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray.
P270 : Do not eat, drink or smoke when using this product.
P271 : Use only outdoors or in a well-ventilated area.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
P362 : Take off contaminated clothing and wash before reuse.
P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell.
P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell.
Related Laws:
RTECS# AC6900000
Transport Information:
HS Number 2928.00.5000
Acetamidoxime: A Useful Reagent for Constructing Heterocyclic Compounds


Experimental procedure1): To a solution of Boc-L-cystine (248.0 g, 0.56 mol), acetamidoxime (89.0 g, 1.20 mol), and 2-Hydroxypyridine N-Oxide (2.9 g, 0.026 mol) in THF (1 L) is added a solution of DCC (250 g, 1.21 mol) in THF (0.8 L) at 0 °C. The mixture is stirred for 16 h while the temperature is allowed to warm to 20 °C. The mixture is cooled to 0 °C and the precipitate is removed by filtration. The filtrate is concentrated in vacuo to a volume of about 0.5 L and then diluted with EtOAc (0.8 L). Upon the addition of H2O (1 L), a precipitate forms which is isolated by filtration to give Boc-L-cystine bis(acetamidoxime) ester (2, 246.6 g) as white crystals. This material is taken up in toluene (0.8 L) and the mixture is heated at reflux for 3 h, the water formed being removed by a Dean-Stark trap. Addition of hexane (3 L) to the cooled mixture leads to crystallization of 3 (215.0 g, 79%) as white crystals.


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