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CAS RN: 2627-69-2 | Product Number: A2528

5-Aminoimidazole-4-carboxamide 1-β-D-Ribofuranoside


Purity: >98.0%(HPLC)
Synonyms:
  • 5-Amino-1-(β-D-ribofuranosyl)-1H-imidazole-4-carboxamide
  • Acadesine
  • AICAR
Documents:
50MG
$80.00
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Product Number A2528
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__9H__1__4N__4O__5 = 258.23  
Physical State (20 deg.C) Solid
Storage Temperature <0°C
Condition to Avoid Heat Sensitive
CAS RN 2627-69-2
Reaxys Registry Number 38255
PubChem Substance ID 253659575
Merck Index (14) 16
MDL Number

MFCD00869751

Specifications
Appearance White to Light yellow to Light red powder to crystal
Purity(HPLC) min. 98.0 area%
Elemental analysis(Nitrogen) 21.20 to 22.00 %
Specific rotation [a]20/D -61.0 to -66.0 deg(C=1、H2O)
Properties (reference)
Melting Point 212 °C
Specific Rotation -63° (C=1,H2O)
Maximum Absorption Wavelength 265(NaOH) nm
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
Precautionary Statements P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P302 + P352 : IF ON SKIN: Wash with plenty of soap and water.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
P362 : Take off contaminated clothing and wash before reuse.
Related Laws:
Transport Information:
HS Number 2933.29.9000
Application
Acadesine (AICAR): AMP-Activated Protein Kinase Activator

5-Aminoimidazole-4-carboxamide 1-β-D-ribofuranoside (Acadesine or AICAR) has been extensively used in vitro and in vivo to activate AMP-activated protein kinase (AMPK). AMPK stimulates energy production via glucose and lipid metabolism, whereas it inhibits energy consuming functions, such as protein and cholesterol synthesis. Therefore, acadesine may have applications in treating disorders such as type 2 diabetes and Alzheimer's disease. Recently, it has been shown that acadesine induces leukemia apoptosis. (The product is for research purpose only.)

References


PubMed Literature


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