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CAS RN: 344423-98-9 | Product Number: A2476

Atorvastatin Calcium Salt Trihydrate


Purity: >98.0%(HPLC)(N)
Synonyms:
Documents:
1G
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Product Number A2476
Purity / Analysis Method >98.0%(HPLC)(N)
Molecular Formula / Molecular Weight C__6__6H__6__8CaF__2N__4O__1__0·3H__2O = 1209.41  
Physical State (20 deg.C) Solid
CAS RN 344423-98-9
Related CAS RN 134523-03-8&134523-00-5
PubChem Substance ID 135727313
Merck Index (14) 864
MDL Number

MFCD09752074

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(with Total Nitrogen) min. 98.0 %(calcd.on anh.substance)
Specific rotation [a]20/D -7.0 to -10.0 deg(C=1、DMSO)(calcd.on anh.substance)
Water 3.5 to 5.5 %
Properties (reference)
Specific Rotation -8° (C=1,DMSO)
Solubility in water Insoluble
Solubility (very soluble in) Methanol
Solubility (insoluble in) Ethanol
GHS
Related Laws:
Transport Information:
HS Number 2933.99.8290
Application
Atorvastatin Calcium Salt: A Most Potent HMG-CoA Reductase Inhibitor

Enzyme HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase catalyzes the rate-limiting step in cholesterol biosynthesis. Statins inhibit the action of HMG-CoA reductase resulting in the reduction of low-density-lipoprotein (LDL) and total cholesterol levels. Especially in statins, atorvastatin calcium salt is a most potent statin because it has a long half-life and metabolites which also play a role as an HMG-CoA reductase inhibitor. Atorvastatin metabolized by cytochrome P450 3A4 (CYP3A4). In addition, we have a synthetic intermediate (atorvastatin acetonide tert-butyl ester [B3690]) for atorvastatin calcium salt. (The product is for research purpose only.)

References


PubMed Literature


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