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CAS RN: 78110-38-0 | Product Number: A2466

Aztreonam


Purity: >98.0%(HPLC)
Synonyms:
  • 2-[[(Z)-[1-(2-Amino-4-thiazolyl)-2-[[(2S,3S)-2-methyl-4-oxo-1-sulfo-3-azetidinyl]amino]-2-oxoethylidene]amino]oxy]-2-methylpropionic Acid
Documents:
500MG
$68.00
5   3   ≥20 
5G
$345.00
3   2   ≥20 

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Product Number A2466
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__1__3H__1__7N__5O__8S__2 = 435.43  
Physical State (20 deg.C) Solid
CAS RN 78110-38-0
Reaxys Registry Number 3577211
PubChem Substance ID 160871057
Merck Index (14) 925
MDL Number

MFCD00072145

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Neutralization titration) min. 95.0 %
Specific rotation [a]20/D -26.0 to -32.0 deg(C=0.5、H2O)
Properties (reference)
Melting Point 227 °C(dec.)
Specific Rotation -28° (C=0.5,H2O)
Solubility in water Practically insoluble
Solubility (very slightly) Methanol
Solubility (insoluble in) Ethanol
GHS
Related Laws:
RTECS# UA2451400
Transport Information:
HS Number 2934.20.8000
Application
Aztreonam: The First Monobactam Antibiotic with Resistance to beta-Lactamases

Aztreonam is the first synthetic monocyclic beta-lactam antibiotic (monobactam). It has strong activity against susceptible gram-negative bacteria, including Pseudomonas aeruginosa. It has no useful activity against gram-positive bacteria or anaerobes. It is highly resistant to hydrolytic inactivation caused by plasmid-mediated or chromosomally mediated beta-lactamases, but is inactivated by extended-spectrum beta-lactamases (ESBLs).

References


PubMed Literature


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