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CAS RN: 30516-87-1 | Product Number: A2052

3'-Azido-3'-deoxythymidine


Purity: >98.0%(T)
Synonyms:
  • Azidothymidine
  • AZT
  • 1-(3-Azido-2,3-dideoxy-β-D-ribofuranosyl)thymine
  • Zidovudine
Documents:
1G
$43.00
2   5   19  
5G
$125.00
3   1   16  

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Product Number A2052
Purity / Analysis Method >98.0%(T)
Molecular Formula / Molecular Weight C__1__0H__1__3N__5O__4 = 267.25  
Physical State (20 deg.C) Solid
Condition to Avoid Hygroscopic
CAS RN 30516-87-1
Reaxys Registry Number 3595791
PubChem Substance ID 87559740
SDBS (AIST Spectral DB) 51948
Merck Index (14) 10123
MDL Number

MFCD00006536

Specifications
Appearance White to Almost white powder to crystal
Purity(Neutralization titration) min. 98.0 %
Melting point 122.0 to 126.0 °C
Specific rotation [a]20/D +43.0 to +51.0 deg(C=1, H2O)
Properties (reference)
Melting Point 124 °C
Specific Rotation 47° (C=1,H2O)
Solubility in water Slightly soluble
Degree of solubility in water 20 g/l   25 °C
Solubility (soluble in) Ethanol
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H351 : Suspected of causing cancer.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P405 : Store locked up.
Related Laws:
RTECS# XP2072000
Transport Information:
HS Number 2940.00.6000
Application
Synthesis of Novel Potent Anti-HIV Compounds via Click Chemistry

References

Clicking 3'-Azidothymidine into Novel Potent Inhibitors of Human Immunodeficiency Virus

V. R. Sirivolu, S. K. V. Vernekar, T. Ilina, N. S. Myshakina, M. A. Parniak, Z. Wang, J. Med. Chem. 2013, 56, 8765.


Application
Synthesis of Antitumor Compounds via Click Chemistry

References

Synthesis and Antitumor Activities of Novel 1,2,3-Triazole-fused Oligoconjugates Based on Nucleoside and Saccharide

P. Jin, J. Lu, C. Zhao, Y. Ju, Chin. J. Org. Chem. 2012, 32, 1673.


Application
Zidovudine (AZT): a Nucleotide Reverse Transcriptase Inhibitor (NRTI)

3'-Azido-2',3'-dideoxythymidine (AZT, Zidovudine) is a nucleotide reverse transcriptase inhibitor (NRTI). It shows activity against human immunodeficiency virus (HIV). In 1985, AZT was found to inhibit the HIV in vitro (Mitsuya et al.). AZT, after conversion to AZT-5'-triphosphate (AZT-TP) by cellular enzymes, inhibits HIV-reverse transcriptase (HIV-RT).

References


PubMed Literature


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