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CAS RN: 320-67-2 | Product Number: A2033

5-Azacytidine


Purity: >98.0%(T)
Synonyms:
  • 4-Amino-1-(β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one
  • Ladakamycin
Documents:
100MG
$42.00
7   11   ≥20 
1G
$221.00
2   5   ≥20 

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Product Number A2033
Purity / Analysis Method >98.0%(T)
Molecular Formula / Molecular Weight C__8H__1__2N__4O__5 = 244.21  
Physical State (20 deg.C) Solid
Storage Temperature <0°C
Condition to Avoid Light Sensitive,Heat Sensitive
CAS RN 320-67-2
Reaxys Registry Number 620461
PubChem Substance ID 87559665
Merck Index (14) 887
MDL Number

MFCD00006539

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 97.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Properties (reference)
Melting Point 216 °C(dec.)
Solubility in water Soluble
GHS
Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H302 : Harmful if swallowed.
H340 : May cause genetic defects.
H350 : May cause cancer.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P270 : Do not eat, drink or smoke when using this product.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
P405 : Store locked up.
Related Laws:
RTECS# XZ3017500
Transport Information:
HS Number 2940.00.6000
Application
An Inhibitor of DNA Methylation

The cytidine analogs 5-azacytidine and 5-aza-2'-deoxycytidine [A2232] are inhibitors of DNA methyltransferases (DNMTs) which catalyze the transfer of a methyl group to DNA. DNA methylation is an epigenetic factor and plays an important role in regulating gene expression. 5-Azacytidine and 5-aza-2'-deoxycytidine are the currently most advanced agents for epigenetic cancer therapies. (The product is for research purpose only.)

References


Application
iPS cell generation boosting compounds

References

Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds

D. Huangfu, R. Maehr, W. Guo, A. Eijkelenboom, M. Snitow, A. E. Chen, D. A. Melton, Nat. Biotechnol. 2008, 26, 795.


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