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CAS RN: 59277-89-3 | Product Number: A1915

Acyclovir


Purity: >98.0%(HPLC)
Synonyms:
  • Acycloguanosine
  • 9-[(2-Hydroxyethoxy)methyl]guanine
  • Aciclovir
Documents:
1G
$44.00
12   1   3  
5G
$120.00
7   4   10  
25G
$398.00
9   1   ≥20 

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Product Number A1915
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__8H__1__1N__5O__3 = 225.21  
Physical State (20 deg.C) Solid
CAS RN 59277-89-3
Reaxys Registry Number 1219402
PubChem Substance ID 87559875
SDBS (AIST Spectral DB) 52102
Merck Index (14) 146
Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 94.0 %
Properties (reference)
Melting Point 262 °C
GHS
Signal Word Warning
Hazard Statements H320 : Causes eye irritation.
Precautionary Statements P264 : Wash skin thoroughly after handling.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Related Laws:
RTECS# UP0791400
Transport Information:
HS Number 2933.99.9701
Application
Acyclovir: An Antiherpesvirus Agent

Acyclovir, an acyclic guanine nucleoside analog developed by Elion and Hitchings, is an antiherpesvirus agent like penciclovir [P2164]. Valacyclovir [V0111] is a prodrug of acyclovir. Acyclovir is active against most species in the herpesvirus family. It depends on the activity of the viral enzyme thymidine kinase (TK) to convert the agent to a monophosphate form and subsequently interfere with viral DNA replication. In contrast, human cellular TK have very little ability to add the initial phosphate group to acyclovir, which has extremely low toxicity for human cell. The spectrum of activity of acyclovir against human herpesviruses is similar to that of penciclovir, both compounds having good activity against herpes simplex viruses types 1 and 2 (HSV-1, HSV-2), varicella-zoster virus (VZV), and Epstein-Barr virus (EBV). Like penciclovir, acyclovir has slight activity against cytomegalovirus (CMV).

References


PubMed Literature


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