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CAS RN: 315-30-0 | Product Number: A0907

Allopurinol


Purity: >98.0%(T)
Synonyms:
  • 4-Hydroxypyrazolo[3,4-d]pyrimidine
  • 1H-Pyrazolo[3,4-d]pyrimidin-4-ol
Documents:
25G
$30.00
7   2   ≥20 
250G
$150.00
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Product Number A0907
Purity / Analysis Method >98.0%(T)
Molecular Formula / Molecular Weight C__5H__4N__4O = 136.11  
Physical State (20 deg.C) Solid
CAS RN 315-30-0
Reaxys Registry Number 608611
PubChem Substance ID 87562416
SDBS (AIST Spectral DB) 4122
Merck Index (14) 279
MDL Number

MFCD00599413

Specifications
Appearance White to Light yellow powder to crystal
Purity(Neutralization titration) min. 98.0 %
Solubility in 1mol/L NaOH almost transparency
Properties (reference)
Melting Point 384 °C
Solubility in water Insoluble
Degree of solubility in water 0.48 g/l   25 °C
Solubility (insoluble in) Chloroform,Ether,Ethanol
GHS
Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H301 : Toxic if swallowed.
H317 : May cause an allergic skin reaction.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves.
P272 : Contaminated work clothing must not be allowed out of the workplace.
P302 + P352 : IF ON SKIN: Wash with plenty of soap and water.
P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention.
P363 : Wash contaminated clothing before reuse.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P405 : Store locked up.
Related Laws:
RTECS# UR0785000
Transport Information:
UN Number (DOT-AIR) UN2811
Class (DOT-AIR) 6.1
Packing Group (TCI-A) III
HS Number 2933.99.9701
Application
Allopurinol: A Purine Inhibitor of Xanthine Oxidase (XO)

Allopurinol is a xanthine oxidase (XO) inhibitor which inhibits the activity of xanthine oxidase, an enzyme involved in purine metabolism. XO catalyzes the oxidative hydroxylation of hypoxanthine [H0311] to xanthine [X0004] and further catalyze the oxidation of xanthine to uric acid [U0018]. Hence, XO inhibitors can lower serum levels of uric acid. In additon, febuxostat [F0847] is a non-purine inhibitor of XO. Allopurinol, first synthesized as a potential antitumor agent, is nowadays a clinical useful XO inhibitor used in the treatment of gout and the prevention of tumor lysis syndrome. (The product is for research purpose only.)

References


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