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CAS RN: 75-36-5 | Product Number: A0082

Acetyl Chloride


Purity: >98.0%(GC)(T)
Synonyms:
Documents:
100G
$20.00
10   13   ≥20 
500G
$49.00
13   6   ≥20 

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Product Number A0082
Purity / Analysis Method >98.0%(GC)(T)
Molecular Formula / Molecular Weight C__2H__3ClO = 78.50  
Physical State (20 deg.C) Liquid
Storage Temperature 0-10°C
Store Under Inert Gas Store under inert gas
Condition to Avoid Moisture Sensitive,Heat Sensitive
CAS RN 75-36-5
Reaxys Registry Number 605303
PubChem Substance ID 87561779
Merck Index (14) 85
Specifications
Appearance Colorless to Light yellow clear liquid
Purity(GC) min. 98.0 %
Purity(Argentmetric Titration) min. 98.0 %
Properties (reference)
Melting Point -112 °C
Boiling Point 52 °C
Flash point 5 °C
Specific Gravity (20/20) 1.10
Refractive Index 1.39
Solubility (miscible with) Ether,Benzene,Chloroform
Solubility (soluble in) Acetone
GHS
Pictogram Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H302 : Harmful if swallowed.
H314 : Causes severe skin burns and eye damage.
H335 : May cause respiratory irritation.
H412 : Harmful to aquatic life with long lasting effects.
H225 : Highly flammable liquid and vapor.
H290 : May be corrosive to metals.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray.
P273 : Avoid release to the environment.
P270 : Do not eat, drink or smoke when using this product.
P240 : Ground/bond container and receiving equipment.
P210 : Keep away from heat/sparks/open flames/hot surfaces. No smoking.
P233 : Keep container tightly closed.
P234 : Keep only in original container.
P243 : Take precautionary measures against static discharge.
P241 : Use explosion-proof electrical/ ventilating/ lighting/ equipment.
P242 : Use only non-sparking tools.
P271 : Use only outdoors or in a well-ventilated area.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P370 + P378 : In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish.
P390 : Absorb spillage to prevent material damage.
P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower.
P301 + P330 + P331 : IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P363 : Wash contaminated clothing before reuse.
P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor.
P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor.
P403 + P233 : Store in a well-ventilated place. Keep container tightly closed.
P403 + P235 : Store in a well-ventilated place. Keep cool.
P406 : Store in corrosive resistant container with a resistant inner liner.
P405 : Store locked up.
Related Laws:
RTECS# AO6390000
Transport Information:
UN Number (DOT-AIR) UN1717
Class (DOT-AIR) 3
Packing Group (TCI-A) II
HS Number 2915.90.1800
Application
Acetylation of Alcohols using Acetylating Reagents and Acid Catalysts

References

1)Facile Catalyzed Acylation of Alcohols, Phenols, Amines and Thiols Based on ZrOCl2·8H2O and Acetyl Chloride in Solution and in Solvent-free Conditions

R. Ghosh, S. Maiti, A. Chakraborty, Tetrahedron Lett. 2005, 46, 147.

2)Protection for the Hydroxyl Group, Including 1,2- and 1,3-Diols

P. G. M. Wuts, in Greene’s Protective Groups in Organic Synthesis, 5th ed., ed. by P. G. M. Wuts, John Wiley & Sons, Inc., Hoboken, New Jersey, 2014, Chap. 2, 17.


Application
Acetylation of Alcohols using Acetylating Reagents and Base Catalysts

References

1)An Extremely Simple, Convenient, and Selective Method for Acetylating Primary Alcohols in the Presence of Secondary Alcohols

K. Ishihara, H. Kurihara, H. Yamamoto, J. Org. Chem. 1993, 58, 3791.

2)4-Dialkylaminopyridines as Highly Active Acylation Catalysts. [New synthetic method (25)]

G. Höfle, W. Steglich, H. Vorbrüggen, Angew. Chem. Int. Ed. 1978, 17, 569.

3)Protection for the Hydroxyl Group, Including 1,2- and 1,3-Diols

P. G. M. Wuts, in Greene’s Protective Groups in Organic Synthesis, 5th ed., ed. by P. G. M. Wuts, John Wiley & Sons, Inc., Hoboken, New Jersey, 2014, Chap. 2, 17.


Application
Deprotection of MOM Groups using Acetyl Chloride and Methanol

References

Protection for the Hydroxyl Group, Including 1,2- and 1,3-Diols

P. G. M. Wuts, in Greene’s Protective Groups in Organic Synthesis, 5th ed., ed. by P. G. M. Wuts, John Wiley & Sons, Inc., Hoboken, New Jersey, 2014, Chap. 2, 17.


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