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Fluorination Reagents [Synthetic Reagents]
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Introduction of fluorine into a certain position of bioactive compound such as a pharmaceutical and an agricultural chemical may remarkably reduce the toxicity of the compound, or improve the efficiency of medicine. This is due to the mimic and blocking effect characterized by fluorine. Many compounds, such as 5-fluorouracil, have been reported as success case. Attempts to efficiently synthesize fluorine-containing compounds are performed in many fields. Methods to introduce fluorine into a certain position through the use of fluorinating agents have been reported.
Fluorine, difluoromethyl group, trifluoromethyl group, trifluoromethlythio group and etc. are known as below. This page shows fluorinating agents categorized by functional group insertion.
Fluorine, difluoromethyl group, trifluoromethyl group, trifluoromethlythio group and etc. are known as below. This page shows fluorinating agents categorized by functional group insertion.
Topics & Information
References
- 1) T. Umemoto, R. P. Singh, Y. Xu, N. Saito, J. Am. Chem. Soc. 2010, 132, 18199.
- 2) M. Kikuchi, T. Onozawa, Yuki Gosei Kagaku Kyokaishi (J. Synth. Org. Chem., Jpn.) 1997, 55, 72.
- 3) (a) R. S. H. Liu, H. Matsumoto, A. E. Asato, M. Denny, Y. Shichida, T. Yoshizawa, F. W. Dahlquist, J. Am. Chem. Soc. 1981, 103, 7195.
- 4) F. Camps, J. Coll, G. Fabrias, A. Guerrero, Tetrahedron 1984, 40, 2871.
- 5) Ph. Coutrot, C. Grison, R. Sauvetre, J. Organomet. Chem. 1987, 332, 1.
- 6) S. Noritake, N. Shibata, S. Nakamura, T. Toru, M. Shiro, Eur. J. Org. Chem. 2008, 3465.
Fluorination Reagents, Fluorinated Building BlocksNew Stable Nucleophilic Fluorinating Reagent (FLUOLEAD)Trifluoromethylating ReagentsDifluorocarbene PrecursorsTrifluoromethylthiolation Reagents3,3,3-Trifluoropropenylation ReagentSulfinate Salt for Trifluoromethylation via C-H Bond ActivationUnique Fluorinating Reagent with Various ReactivitiesTrifluoromethylating Reagents Used in Nucleophilic ReactionsCopper Complexes for Trifluoromethylation via Oxidative Cross-couplingElectrophilic Trifluoromethylating Agent: Umemoto's Reagent IIStable Hydrogen Fluoride (HF) Complex for Nucleophilic Fluorination: DMPU-HFDeoxyfluorination Reagents by the Ritter GroupHypervalent Iodine Compound for Trifluoromethylthiolation: Shibata Reagent IIDifluoromethylation Reagents, Difluoromethylenation ReagentsMorpholine Derivative Usable for TrifluoromethylationHypervalent Iodine Reagentfor Photoredox TrifluoromethylationSulfonium Salt for Photo-catalytic Difluoromethylation