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CAS RN: 632-85-9 | Product Number: W0010

Wogonin


Purity: >98.0%(HPLC)
Synonyms:
Documents:
50MG
$136.00
13   2  
250MG
$407.00
3   3  

* Please contact our distributors or TCI to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.


Product Number W0010
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__1__6H__1__2O__5 = 284.27  
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Condition to Avoid Heat Sensitive
Packaging and Container 250MG-Glass Bottle with Plastic Insert (View image),  50MG-Glass Bottle with Plastic Insert (View image)
CAS RN 632-85-9
Reaxys Registry Number 287152
PubChem Substance ID 354335738
MDL Number

MFCD00017736

Specifications
Appearance Light orange to Yellow to Green powder to crystal
Purity(HPLC) min. 98.0 area%
Melting point 205.0 to 209.0 °C
Properties (reference)
Melting Point 207 °C
Maximum Absorption Wavelength 319(EtOH) nm
GHS
Related Laws:
RTECS# LK8331000
Transport Information:
H.S.code* 2932.99-000
*This code is applied to the products when TCI exports from Japan and not for import in your country.
Application
Wogonin: An O-Methylated Monoflavonoid with Various Bioactivities

Wogonin is an O-methylated monoflavonoid found in Scutellaria baicalensis which is one of the most popular and multi-purpose herb used in China traditionally for treatment of various diseases1,2). Wogonin is also one of the active ingredients of Sho-Saiko-To, a Japanese herbal supplement3). It has been reported that wogonin exerts anti-oxidant1), anti-cancer4), anti-inflammatory4,5), anti-viral4,6) and neuroprotective effects7). For your reference, a glycoside of wogonin is wogonoside [W12]. (The product is for research purpose only.)

References

1)Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi

Z. Gao, K. Huang, X. Yang, H. Xu, Biochim. Biophys. Acta, Gen. Subj. 1999, 1472, 643.

2)Characterization of flavonoids in the traditional Chinese herbal medicine-Huangqin by liquid chromatography coupled with electrospray ionization mass spectrometry

J. Han, M. Ye, M. Xu, J. Sun, B. Wang, D. Guo, J. Chromatogr. B 2007, 848, 355.

3)Effects of Sho-saiko-to, a Japanese herbal medicine, on hepatic fibrosis in rats

I. Shimizu, Y.-R. Ma, Y. Mizobuchi, F. Liu, T. Miura, Y. Nakai, M. Yasuda, M. Shiba, T. Horie, S. Amagaya, N. Kawada, H. Hori, S. Ito, Hepatology 1999, 29, 149.

4)New therapeutic aspects of flavones: The anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin (a review)

M. Li-Weber, Cancer Treat. Rev. 2009, 35, 57.

5)Wogonin, baicalin, and baicalein inhibition of inducible nitric oxide synthase and cyclooxygenase-2 gene expressions induced by nitric oxide synthase inhibitors and lipopolysaccharide

Y.-C. Chen, S.-C. Shen, L.-G. Chen, T. J-F Lee, L.-L. Yang, Biochem. Pharmacol. 2001, 61, 1417.

6)Anti-hepatitis B virus activity of wogonin in vitro and in vivo

Q. Guo, L. Zhao, Q. You, Y. Yang, H. Gu, G. Song, N. Lu, J. Xin, Antiviral Res. 2007, 74, 16.

7)Flavonoid wogonin from medicinal herb is neuroprotective by inhibiting inflammatory activation of microglia

H. Lee, Y. O. Kim, H. Kim, S. Y. Kim, H. S. Noh, S. S. Kang, G. J. Cho, W. S. Choi, K. Suk, FASEB J. 2003, 17, 1943.


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