CAS RN: 122852-69-1 | Product Number: A3197
- 2,3,4,5-Tetrahydro-5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-1H-pyrido[4,3-b]indol-1-one Hydrochloride
- 5-Methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one Hydrochloride
|Size||Unit Price||Same Day||2-3 Business Days|
|Purity / Analysis Method||>98.0%(HPLC)|
|Molecular Formula / Molecular Weight||C__1__7H__1__8N__4O·HCl = 330.82|
|Physical State (20 deg.C)||Solid|
|Condition to Avoid||Heat Sensitive|
|Related CAS RN||122852-42-0|
|PubChem Substance ID||354335545|
|Merck Index (14)||308|
|Appearance||White to Light yellow powder to crystal|
|Purity(HPLC)||min. 98.0 area%|
|Melting Point||291 °C|
|Hazard Statements||H301 : Toxic if swallowed.
|Precautionary Statements||P501 : Dispose of contents/ container to an approved waste disposal plant.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P405 : Store locked up.
Alosetron Hydrochloride is a potent and selective 5-HT3 receptor antagonist. 5-Hydroxytryptamine (5-HT) [S37, HCL salt] is a key modulator of gastrointestinal sensorimotor function. 5-HT3 receptors, a subtype of 5-HT receptors, are ligand-gate cation channels that are extensively distributed on enteric neurons in the gastrointestinal tract, as well as other peripheral and central locations. Alosetron inhibits activation of these channels, which results in the modulation of the enteric nervous system. Alosetron is used for the treatment of irritable bowel syndrome (IBS). (The product is for research purpose only.)
Irritable bowel syndrome: New agents targeting serotonin receptor subtypes (a review)
The serotonin signaling system: from basic understanding to drug development for functional GI disorders (a review)
Characterization of the metabolites of alosetron in experimental animals and human
Estimation of alosetron hydrochloride in tablet dosage form by RP-HPLC
A novel reverse phase high-performance liquid chromatography (RP-HPLC-UV) method for the estimation of alosetron HCl and its validation
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