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CAS RN: 122852-69-1 | Product Number: A3197

Alosetron Hydrochloride


Purity: >98.0%(HPLC)
Synonyms:
  • 2,3,4,5-Tetrahydro-5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-1H-pyrido[4,3-b]indol-1-one Hydrochloride
  • 5-Methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one Hydrochloride
Documents:
100MG
$108.00
≥20  10  

* Please contact our distributors or TCI to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.


Product Number A3197
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__1__7H__1__8N__4O·HCl = 330.82  
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Condition to Avoid Heat Sensitive
CAS RN 122852-69-1
Related CAS RN 122852-42-0
PubChem Substance ID 354335545
Merck Index (14) 308
MDL Number

MFCD03453647

Specifications
Appearance White to Light yellow powder to crystal
Purity(HPLC) min. 98.0 area%
Properties (reference)
Melting Point 291 °C
GHS
Pictogram Pictogram
Signal Word Danger
Hazard Statements H301 : Toxic if swallowed.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P405 : Store locked up.
Related Laws:
RTECS# UV1113000
Transport Information:
UN Number UN2811
Class 6.1
Packing Group III
H.S.code* 2933.99-000
*This code is applied to the products when TCI exports from Japan and not for import in your country.
Application
Alosetron Hydrochloride: A Potent and Selective 5-HT3 Receptor Antagonist

Alosetron Hydrochloride is a potent and selective 5-HT3 receptor antagonist. 5-Hydroxytryptamine (5-HT) [S37, HCL salt] is a key modulator of gastrointestinal sensorimotor function. 5-HT3 receptors, a subtype of 5-HT receptors, are ligand-gate cation channels that are extensively distributed on enteric neurons in the gastrointestinal tract, as well as other peripheral and central locations. Alosetron inhibits activation of these channels, which results in the modulation of the enteric nervous system. Alosetron is used for the treatment of irritable bowel syndrome (IBS). (The product is for research purpose only.)

References

Irritable bowel syndrome: New agents targeting serotonin receptor subtypes (a review)

F. De Ponti, M. Tonini, Drugs 2001, 61, 317.

The serotonin signaling system: from basic understanding to drug development for functional GI disorders (a review)

M. D. Gershon, J. Tack, Gastroenterology 2007, 132, 397.

Characterization of the metabolites of alosetron in experimental animals and human

I. M. Ismail, P. D. Andrew, J. Cholerton, A. D. Roberts, G. J. Dear, S. Taylor, K. M. Koch, D. A. Saynor, Xenobiotica 2005, 35, 131.

Estimation of alosetron hydrochloride in tablet dosage form by RP-HPLC

A. Khan, J. V. Rao, R. P. Pulla, S. K. Agrawal, Indo Am. J. Pharm. Sci. 2014, 1, 430.

A novel reverse phase high-performance liquid chromatography (RP-HPLC-UV) method for the estimation of alosetron HCl and its validation

Y. Karthik, B. Babu, S. Meyyanathan, V. Awari, N. Krishnaveni, Acta Chromatogr. 2015, 27, 321.


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