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CAS RN: 55779-18-5 | Product Number: A3146

Arprinocid


Purity: >95.0%(HPLC)
Synonyms:
  • 9-(2-Chloro-6-fluorobenzyl)-9H-purin-6-amine
  • Arpocox
Documents:
50MG
$120.00
6   1  
250MG
$358.00
7   2  

* Please contact our distributors or TCI to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.


Product Number A3146
Purity / Analysis Method >95.0%(HPLC)
Molecular Formula / Molecular Weight C__1__2H__9ClFN__5 = 277.69  
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Store Under Inert Gas Store under inert gas
Condition to Avoid Air Sensitive,Heat Sensitive
CAS RN 55779-18-5
Reaxys Registry Number 827813
PubChem Substance ID 354333137
MDL Number

MFCD00867210

Specifications
Appearance White to Yellow to Orange powder to crystal
Purity(HPLC) min. 95.0 area%
Elemental analysis(Nitrogen) 24.00 to 26.50 %
Melting point 242.0 to 247.0 °C
Properties (reference)
Melting Point 245 °C
Maximum Absorption Wavelength 260(NaOH aq.) nm
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
Precautionary Statements P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P302 + P352 : IF ON SKIN: Wash with plenty of water.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P362 + P364 : Take off contaminated clothing and wash it before reuse.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
Related Laws:
Transport Information:
H.S.code* 2933.99-000
*This code is applied to the products when TCI exports from Japan and not for import in your country.
Application
Arprinocid: An Anticoccidial Agent against Toxoplasma gondii

Arprinocid is an anticoccidial agent. Arprinocid and its main metabolite, arprinocid-1-N-oxide, have been found to exert cidal effect on Toxoplasma gondii in vitro. However, the exact mechanism of action is unknown. (The product is for research purpose only.)

References

Potent in vivo activity of arprinocid, a purine analog against murine toxoplasmosis

B. J. Luft, J. Infect. Dis. 1986, 154, 692.

Toxoplasma gondii: in vivo and in vitro studies of a mutant resistant to arprinocid-N-oxide

E. R. Pfefferkorn, M. E. Eckel, E. McAdams, Exp. Parasitology 1988, 65, 282.

Determination of 20 coccidiostats in milk, duck muscle and non-avian muscle tissue using UHPLC-MS/MS

L. Clarke, M. Moloney, J. O’Mahony, R. O’Kennedy, M. Danaher, Food Addit. Contam. A 2013, 30, 958.


Application
Aprinocid: A Potent Anticoccidial Agent

Aprinocid and its metabolite arprinocid-1-N-oxide [55779-19-6] exhibit potent anticoccidial activity. It is reported that they are interfere with the hypoxanthine and guanine acquisition by Eimeria. (The product is for research purpose only.)

References

Arprinocid, an inhibitor of hypoxanthine-guanine transport

C. C. Wang, R. L. Tolman, P. M. Simashkevich, R. L. Stotish, Biochem. Pharmacol. 1979, 28, 2249.

A comparative study of the biological activities of arprinocid and arprinocid-1-N-oxide

C. C. Wang, P. M. Simashkevich, Mol. Biochem. Parasitology 1980, 1, 335.

Potent in vivo activity of arprinocid, a purine analog against murine toxoplasmosis

B. J. Luft, J Infect Dis. 1986, 154, 692.

Resistance to anticoccidial drugs : Alternative strategies to control coccidiosis in broilers (a review)

H. W. Peek, Utrecht University Repository 2010.

Determination of 20 coccidiostats in egg and avian muscle tissue using ultra high performance liquid chromatography-tandem mass spectrometry

M. Moloney, L. Clarke, J. O’Mahony, A. Gadaj, R. O’Kennedy, M. Danaher, J. Chromatogr. A 2012, 1253, 94.


PubMed Literature


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