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CAS RN: 41294-56-8 | Product Number: A3125

Alfacalcidol


Purity: >95.0%(HPLC)
Synonyms:
  • 1α-Hydroxyvitamin D3
  • 1α-Hydroxycholecalciferol
Documents:
10MG
$108.00
11   4  
50MG
$380.00
8   2  

* Please contact our distributors or TCI to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.


Product Number A3125
Purity / Analysis Method >95.0%(HPLC)
Molecular Formula / Molecular Weight C__2__7H__4__4O__2 = 400.65  
Physical State (20 deg.C) Solid
Storage Temperature -20°C
Store Under Inert Gas Store under inert gas
Condition to Avoid Air Sensitive,Heat Sensitive
Packaging and Container 50MG-Glass Bottle with Plastic Insert (View image)
CAS RN 41294-56-8
Reaxys Registry Number 2064794
PubChem Substance ID 354335206
Merck Index (14) 4819
MDL Number

MFCD00868328

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 95.0 area%
Melting point 134.0 to 138.0 °C
Specific rotation [a]20/D +34.0 to +38.0 deg(C=0.3, CHCL3)
Properties (reference)
Melting Point 136 °C
Specific Rotation 36° (C=0.3,CHCl3)
Maximum Absorption Wavelength 264(Diethyl ether) nm
GHS
Pictogram Pictogram
Signal Word Danger
Hazard Statements H300 + H310 + H330 : Fatal if swallowed, in contact with skin or if inhaled.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray.
P270 : Do not eat, drink or smoke when using this product.
P262 : Do not get in eyes, on skin, or on clothing.
P271 : Use only outdoors or in a well-ventilated area.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing.
P284 : Wear respiratory protection.
P361 + P364 : Take off immediately all contaminated clothing and wash it before reuse.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P302 + P352 + P310 : IF ON SKIN: Wash with plenty of water. Immediately call a POISON CENTER/doctor.
P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor.
P403 + P233 : Store in a well-ventilated place. Keep container tightly closed.
P405 : Store locked up.
Related Laws:
Transport Information:
UN Number UN2811
Class 6.1
Packing Group II
H.S.code* 2906.19-000
*This code is applied to the products when TCI exports from Japan and not for import in your country.
Application
Alfacalcidol: A Prodrug of Calcitriol, the Active Form of Vitamin D3

Alfacalcidol (1α-hydroxyvitamin D3) is a prodrug of calcitriol (1α,25-dihydroxyvitamin D3) [C3078] which is the active form of vitamin D3 (cholecalciferol) [
C0314]. The natural supply of vitamin D3 in human being mainly depends on ultraviolet light for conversion of 7-dehydrocholesterol [CAS: 434-16-2] to vitamin D3 in the skin. The transformation (hydroxylation at position 25) of vitamin D3 is catalyzed by enzymes in the liver and the kidney to produce calcitriol. Calcitriol is active in the regulation of the absorption of calcium from the gastrointestinal tract.
However, alfacalcidol is rapidly hydroxylated to calcitriol in the liver, effectively bypassing the critical renal metabolic conversion. Therefore, alfacalcidol is effective for patients with chronic renal failure to remedy vitamin D3 deficiency, and to increase the bone resorption and the bone formation. (The product is for research purpose only.)

References


PubMed Literature


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