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CAS RN: 14028-44-5 | Product Number: A2499

Amoxapine


Purity: >97.0%(GC)(T)
Synonyms:
  • 2-Chloro-11-(1-piperazinyl)dibenzo[b,f][1,4]oxazepine
Documents:
1G
$90.00
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5G
$313.00
6   2  

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* The storage conditions are subject to change without notice.


Product Number A2499
Purity / Analysis Method >97.0%(GC)(T)
Molecular Formula / Molecular Weight C__1__7H__1__6ClN__3O = 313.79  
Physical State (20 deg.C) Solid
CAS RN 14028-44-5
PubChem Substance ID 181085854
Merck Index (14) 576
MDL Number

MFCD00069210

Specifications
Appearance White to Orange to Green powder to crystal
Purity(GC) min. 97.0 %
Purity(Nonaqueous Titration) min. 97.0 %
Melting point 178.0 to 182.0 °C
Properties (reference)
Melting Point 179 °C
GHS
Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H302 : Harmful if swallowed.
H370 : Causes damage to organs.
H341 : Suspected of causing genetic defects.
H413 : May cause long lasting harmful effects to aquatic life.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P273 : Avoid release to the environment.
P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray.
P270 : Do not eat, drink or smoke when using this product.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor.
P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
P405 : Store locked up.
Related Laws:
RTECS# HQ4025500
Transport Information:
H.S.code* 2934.99-000
*This code is applied to the products when TCI exports from Japan and not for import in your country.
Application
Studies on the Neuropharmacology of Amoxapine
References

Pharmacological profile of antidepressants and related compounds at human monoamine transporters

M. Tatsumi, K. Groshan, R. D. Blakely, E. Richelson, Eur. J. Pharmacol. 1997, 340, 249.

Opioid receptors and neuropeptides in the CNS in rats treated chronically with amoxapine or amitriptyline

M. Hamon, H. Gozlan, S. Bourgoin, J. J. Benoliel, A. Mauborgne, H. Taquet, F. Cesselin, J. A. Mico, Neuropharmacology 1987, 26, 531.

Differential effects of the tricyclic antidepressant amoxapine on glycine uptake mediated by the recombinant GLYT1 and GLYT2 glycine transporters

E. Núñez, B. López-Corcuera, J. Vázquez, C. Giménez, C. Aragón, Br. J. Pharmacol. 2000, 129, 200.

Is amoxapine an atypical antipsychotic? Positron-emission tomography investigation of its dopamine2 and serotonin2 occupancy

S. Kapur, R. Cho, C. Jones, G. McKay, R. B Zipursky, Biol. Psychiatry 1999, 45, 1217.

Multiple mechanisms of hERG liability: K+ current inhibition, disruption of protein trafficking, and apoptosis induced by amoxapine

S. Obers, I. Staudacher, E. Ficker, A. Dennis, R. Koschny, H. Erdal, R. Bloehs, J. Kisselbach, C. A. Karle, P. A. Schweizer, H. A. Katus, D. Thomas, Naunyn-Schmiedeberg's Arch. Pharmacol. 2010, 381, 385.


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