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CAS RN: 53164-05-9 | Product Number: A2452

Acemetacin


Purity: >98.0%(GC)(T)
Synonyms:
  • [1-(4-Chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetoxyacetic Acid
  • 1-(4-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic Acid Carboxymethyl Ester
Documents:
1G
$30.00
12   1  
5G
$86.00
3   2  
25G
$266.00
9   2  

* Please contact our distributors or TCI to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.


Product Number A2452
Purity / Analysis Method >98.0%(GC)(T)
Molecular Formula / Molecular Weight C__2__1H__1__8ClNO__6 = 415.83  
Physical State (20 deg.C) Solid
CAS RN 53164-05-9
Reaxys Registry Number 501672
PubChem Substance ID 135727247
Merck Index (14) 27
MDL Number

MFCD00151473

Specifications
Appearance Light yellow to Yellow to Green powder to crystal
Purity(GC) min. 98.0 %
Purity(Neutralization titration) min. 98.0 %
Melting point 151.0 to 154.0 °C
Properties (reference)
Melting Point 152 °C
GHS
Pictogram Pictogram
Signal Word Danger
Hazard Statements H300 : Fatal if swallowed.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P405 : Store locked up.
Related Laws:
RTECS# NL3521400
Transport Information:
UN Number UN2811
Class 6.1
Packing Group II
H.S.code* 2933.99-000
*This code is applied to the products when TCI exports from Japan and not for import in your country.
Application
Nonsteroidal Antiinflammatory Reagent
References

Nonsteroidal antiinflammatory drugs cause apoptosis and induce cyclooxygenases in chicken embryo fibroblasts

X. Lu, W. Xie, D. Reed, W. S. Bradshaw, D. L. Simmons, Proc. Natl. Acad. Sci. U.S.A. 1995, 92, 7961.

Enhancement of chemotherapeutic drug toxicity to human tumor cells in vitro by a subset of non-steroidal anti-inflammatory drugs (NSAIDs)

C. P. Duffy, C. J. Elliott, R. A. O’Connor, M. M. Heenan, S. Coyle, I. M. Cleary, K. Kavanagh, S. Verhaegen, C. M. O’Loughlin, R. NicAmhlaoibh, M. Clynes, Eur. J. Cancer 1998, 34, 1250.

Lack of effects of acemetacin on signalling pathways for leukocyte adherence may explain its gastrointestinal safety

A. E. Chávez-Piña, L. Vong, W. McKnight, M. Dicay, R. C. O. Zanardo, M. I. Ortiz, G. Castañeda-Hernández, J. L. Wallace, Br. J. Pharmacol. 2008, 155, 857.

Pharmacodynamics of acemetacin

H. Jacobi, H. D. Dell, Arzneim.-Forsch. 1980, 30, 1348.


PubMed Literature


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