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CAS RN: 125-84-8 | Product Number: A1947

DL-Aminoglutethimide


Purity: >98.0%(T)(HPLC)
Synonyms:
  • 3-(4-Aminophenyl)-3-ethylpiperidine-2,6-dione
Documents:
1G
$41.00
13   4  
5G
$115.00
14   7  
25G
$387.00
≥20  10  

* Please contact our distributors or TCI to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.


Product Number A1947
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__1__3H__1__6N__2O__2 = 232.28  
Physical State (20 deg.C) Solid
CAS RN 125-84-8
Reaxys Registry Number 210656
PubChem Substance ID 87558926
Merck Index (14) 440
MDL Number

MFCD00010122

Specifications
Appearance White to Light yellow powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Melting point 150.0 to 154.0 °C
Solubility in Acetone very faint turbidity
Properties (reference)
Melting Point 152 °C
Solubility (soluble in) Acetone
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
Precautionary Statements P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P302 + P352 : IF ON SKIN: Wash with plenty of water.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P362 + P364 : Take off contaminated clothing and wash it before reuse.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
Related Laws:
RTECS# MA4026950
Transport Information:
H.S.code* 2933.39-000
*This code is applied to the products when TCI exports from Japan and not for import in your country.
Application
DL-Aminoglutethimide: A Potent but Nonselective Aromatase Inhibitor

DL-Aminoglutethimide is a first generation, and a potent but nonselective aromatase inhibitor. Aminoglutethimide inhibits the enzymatic side-chain cleavage of cholesterol [C0318] to pregnenolone [P0786], mediated through the binding of aminoglutethimide to cytochrome P 450, resulting in a decrease in the production of adrenal glucocorticoids, mineralocorticoids, estrogens, and androgens. Besides, aminoglutethimide-P450 complexes block enzymatic 11- and 18-hydroxylation steps required for the aromatization of androgens to estrogens. Aminoglutethimide is used for the treatment of Cushing’s syndrome, breast and prostate cancer. (The product is for research purpose only.)

References


PubMed Literature


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