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CAS RN: 665-66-7 | Product Number: A0588

1-Adamantanamine Hydrochloride


Purity: >99.0%(T)
Synonyms:
  • 1-Aminoadamantane Hydrochloride
  • Amantadine Hydrochloride
  • 1-Adamantylamine Hydrochloride
Documents:
25G
$85.00
≥20  ≥20 
250G
$419.00
3   3  

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* The storage conditions are subject to change without notice.


Product Number A0588
Purity / Analysis Method >99.0%(T)
Molecular Formula / Molecular Weight C__1__0H__1__7N·HCl = 187.71  
Physical State (20 deg.C) Solid
CAS RN 665-66-7
Related CAS RN 768-94-5
Reaxys Registry Number 4198854
PubChem Substance ID 87562172
MDL Number

MFCD00074723

Specifications
Appearance White to Almost white powder to crystal
Purity(Nonaqueous Titration) min. 99.0 %
Purity(Argentmetric Titration) min. 99.0 %
Solubility in Water almost transparency
Properties (reference)
Melting Point 360 °C
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H302 : Harmful if swallowed.
H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P302 + P352 : IF ON SKIN: Wash with plenty of water.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P362 + P364 : Take off contaminated clothing and wash it before reuse.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
Related Laws:
RTECS# AU4375000
Transport Information:
H.S.code* 2921.30-000
*This code is applied to the products when TCI exports from Japan and not for import in your country.
Application
1-Adamantanamine Hydrochloride: A Dopamine Receptor Agonist and an Anti-Influenza A Virus Agent

1-Adamantanamine hydrochloride and its free base [A2318] are dopamine receptor agonists and anti-influenza A virus agents, similarly rimantadine hydrochloride [R0070]. 1-Amantadine was originally developed as an antiviral agent. One day, a single patient noticed relief in her Parkinson’s disease symptoms after taking amantadine for a flu infection, and this observation led to a new drug indication.1)
These mechanisms of action are not fully understood. However, there is evidence to suggest that 1-adamantanamine act as a dopamine receptor agonist by enhancing the synthesis and release of dopamine from nerve cells and delaying the reuptake into synaptic vesicles.2,3)
In addition, 1-adamantanamine inhibits the replication of influenza A viruses by preventing the release of infectious viral RNA into the host cell nucleus by interfering with the function of the transmembrane of the viral M2 protein.4,5) (The product is for research purpose only.)

References


PubMed Literature


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