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CAS RN: 54-62-6 | Product Number: A0410

Aminopterin Hydrate

Purity: >97.0%(T)(HPLC)
  • 4-Aminofolic Acid Hydrate
  • 4-Amino-PGA Hydrate
  • 4-Aminopteroyl-L-glutamic Acid Hydrate
≥20  ≥20 
9   10  

* Please contact our distributors or TCI to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.

Product Number A0410
Purity / Analysis Method >97.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__1__9H__2__0N__8O__5 = 440.42  
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Store Under Inert Gas Store under inert gas
Condition to Avoid Air Sensitive,Heat Sensitive
CAS RN 54-62-6
Reaxys Registry Number 69045
PubChem Substance ID 125308158
Merck Index (14) 472
MDL Number


Appearance White to Amber powder to crystal
Purity(HPLC) min. 97.0 area%
Purity(Neutralization titration) min. 97.0 %(calcd.on anh.substance)
Specific rotation [a]20/D +18.0 to +22.0 deg(C=1、0.1mol/LNaOH sol.)(calcd.on anh.substance)
Water 3.0 to 10.0 %
Properties (reference)
Melting Point 222 °C(dec.)
Specific Rotation 20° (C=1,0.1mol/L NaOH)
Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H300 : Fatal if swallowed.
H360 : May damage fertility or the unborn child.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P270 : Do not eat, drink or smoke when using this product.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P405 : Store locked up.
Related Laws:
RTECS# MA1050000
Transport Information:
UN Number UN2811
Class 6.1
Packing Group I
H.S.code* 2933.59-000
*This code is applied to the products when TCI exports from Japan and not for import in your country.
Aminopterin: A Dihydrofolic Acid Reductase (DHFR) Inhibitor

Aminopterin, an amino derivative of folic acid [F0043], is a dihydrofolic acid reductase (DHFR) inhibitor. DHFR is an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid, using nicotinamide adenine dinucleotide phosphate (NADPH) as electron donor, and a key enzyme in the synthesis of thymidylate and DNA. The inhibition causes the depletion of nucleotide precursors and inhibition of DNA. Aminopterin used to use as an antineoplastic agent in the treatment of leukemia. In the 1950’s, a less potent but less toxic methotrexate [M1664] began to replace in clinical use. (The product is for research purpose only.)


PubMed Literature

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