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CAS RN: 129-56-6 | Product Number: A2548


Purity: >95.0%(HPLC)
  • Dibenzo[cd,g]indazol-6(2H)-one
  • SP 600125
3   17  

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Product Number A2548
Purity / Analysis Method >95.0%(HPLC)
Molecular Formula / Molecular Weight C__1__4H__8N__2O = 220.23  
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Condition to Avoid Heat Sensitive
CAS RN 129-56-6
Reaxys Registry Number 746890
PubChem Substance ID 253659651
MDL Number


Appearance Light yellow to Yellow to Green powder to crystal
Purity(HPLC) min. 95.0 area%
Elemental analysis(Nitrogen) 12.1 to 13.3 %
Properties (reference)
Melting Point 282 °C
Related Laws:
EC Number 204-955-6
RTECS# CB4585000
Transport Information:
HS Number 2933998090

PEDF induces p53-mediated apoptosis through PPAR gamma signaling in human umbilical vein endothelial cells

T.C. Ho, S.L. Chen, Y.C. Yang, C.L. Liao, H.C. Cheng, Y.P. Tsao, Cardiovasc. Res. 2007, 76, 213.

Nongenotropic, anti-apoptotic signaling of 1α,25(OH)2-vitamin D3 and analogs through the ligand binding domain of the vitamin D receptor in osteoblasts and osteocytes: MEDIATION BY Src, PHOSPHATIDYLINOSITOL 3-, AND JNK KINASES

A.M. Vertino, C.M. Bula, J.R. Chen, M. Almeida, L. Han, T. Bellido, S. Kousteni, A.W. Norman, S.C. Manolagas, J. Biol. Chem. 2005, 280, 14130.

c-Jun N-Terminal Kinase (JNK) Inhibitor

1)SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

B. L. Bennett, D. T. Sasaki, B. W. Murray, E. C. O’Leary, S. T. Sakata, W. Xu, J. C. Leisten, A. Motiwala, S. Pierce, Y. Satoh, S. S. Bhagwat, A. M. Manning, D. W. Anderson, Proc. Natl. Acad. Sci. USA 2001, 98, 13681.

2)Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125

Y.-S. Heo, S.-K. Kim, C. I. Seo, Y. K. Kim, B.-J. Sung, H. S. Lee, J. I. Lee, S. Y. Park, J. H. Kim, K. Y. Hwang, Y.-L. Hyun, Y. H. Jeon, S. Ro, J. M. Cho, T. G. Lee, C.-H. Yang, EMBO J. 2004, 23, 2185.

3)A mammalian scaffold complex that selectively mediates MAP kinase activation

A. J. Whitmarsh, J. Cavanagh, C. Tournier, J. Yasuda, R. J. Davis, Science 1998, 281, 1671.

4)Scaffold proteins of MAP-kinase modules

D. N. Dhanasekaran, K. Kashef, C. M. Lee, H. Xu, E. P. Reddy, Oncogene 2007, 26, 3185.

5)Differential targeting of MAP kinases to the ETS-domain transcription factor Elk-1

S.-H. Yang, A. J. Whitmarsh, R. J. Davis, A. D. Sharrocks, EMBO J. 1998, 17, 1740.

PubMed Literature


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