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CAS RN: 549-18-8 | Product Number: A0908

Amitriptyline Hydrochloride

Purity: >98.0%(T)(HPLC)
5   18  

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Product Number A0908
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__2__0H__2__3N·HCl = 313.87  
Physical State (20 deg.C) Solid
Condition to Avoid Light Sensitive
CAS RN 549-18-8
Related CAS RN 50-48-6
Reaxys Registry Number 4164595
PubChem Substance ID 87562417
Merck Index (14) 487
MDL Number


Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Melting point 195.0 to 199.0 °C
Solubility in Water almost transparency
Properties (reference)
Melting Point 195 °C
Solubility in water Soluble
Pictogram Pictogram
Signal Word Danger
Hazard Statements H301 : Toxic if swallowed.
H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
Related Laws:
EC Number 208-964-6
RTECS# HO9450000
Transport Information:
UN Number UN2811
Class 6.1
Packing Group III
HS Number 2921490090
Amitriptyline Hydrochloride: An Inhibitor of Serotonin or Noradrenaline Re-Uptake Transporters

Amitriptyline hydrochloride is the most widely used tricyclic antidepressant agent with sedative effects. The mechanism of action of amitriptyline is still not fully understood. However, amitriptyline works as an inhibitor of serotonin (5-hydroxytryptamine, 5HT [S0370]) or L-noradrenaline [A0906] re-uptake transporters in brain neurons. This inhibition is believed by some to underlie the antidepressant activity of amitriptyline. Amitriptyline undergoes extensive metabolism in the liver, primarily through N-demethylation, to nortriptyline [N0957]. (The product is for research purpose only.)


PubMed Literature

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