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CAS RN: 632-85-9 | 产品编码: W0010

Wogonin


纯度/分析方法: >98.0%(HPLC)
别名:
  • 汉黄芩素
文档:
50MG
¥ 1,190.00
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250MG
¥ 3,490.00
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产品编码 W0010
纯度/分析方法 >98.0%(HPLC)
分子式/分子量 C__1__6H__1__2O__5 = 284.27  
外观与形状(20°C) 固体
储存温度 0-10°C
应避免的情况 加热
CAS RN 632-85-9
Reaxys-RN 287152
PubChem物质ID 354335738
MDL编号

MFCD00017736

技术规格
Appearance Light orange to Yellow to Green powder to crystal
Purity(HPLC) min. 98.0 area%
Melting point 205.0 to 209.0 °C
物性(参考值)
熔点 207 °C
最大吸收波长 319(EtOH) nm
GHS
信号词 警告
危险性说明 H303 : 吞咽可能有害。
防范说明 P312 : 如感觉不适,呼叫急救中心/医生。
相关法规
RTECS# LK8331000
运输信息
监管条件代码(*)
应用
Wogonin: An O-Methylated Monoflavonoid with Various Bioactivities

Wogonin is an O-methylated monoflavonoid found in Scutellaria baicalensis which is one of the most popular and multi-purpose herb used in China traditionally for treatment of various diseases1,2). Wogonin is also one of the active ingredients of Sho-Saiko-To, a Japanese herbal supplement3). It has been reported that wogonin exerts anti-oxidant1), anti-cancer4), anti-inflammatory4,5), anti-viral4,6) and neuroprotective effects7). For your reference, a glycoside of wogonin is wogonoside [W12]. (The product is for research purpose only.)

References

1)Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi

Z. Gao, K. Huang, X. Yang, H. Xu, Biochim. Biophys. Acta, Gen. Subj. 1999, 1472, 643.

2)Characterization of flavonoids in the traditional Chinese herbal medicine-Huangqin by liquid chromatography coupled with electrospray ionization mass spectrometry

J. Han, M. Ye, M. Xu, J. Sun, B. Wang, D. Guo, J. Chromatogr. B 2007, 848, 355.

3)Effects of Sho-saiko-to, a Japanese herbal medicine, on hepatic fibrosis in rats

I. Shimizu, Y.-R. Ma, Y. Mizobuchi, F. Liu, T. Miura, Y. Nakai, M. Yasuda, M. Shiba, T. Horie, S. Amagaya, N. Kawada, H. Hori, S. Ito, Hepatology 1999, 29, 149.

4)New therapeutic aspects of flavones: The anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin (a review)

M. Li-Weber, Cancer Treat. Rev. 2009, 35, 57.

5)Wogonin, baicalin, and baicalein inhibition of inducible nitric oxide synthase and cyclooxygenase-2 gene expressions induced by nitric oxide synthase inhibitors and lipopolysaccharide

Y.-C. Chen, S.-C. Shen, L.-G. Chen, T. J-F Lee, L.-L. Yang, Biochem. Pharmacol. 2001, 61, 1417.

6)Anti-hepatitis B virus activity of wogonin in vitro and in vivo

Q. Guo, L. Zhao, Q. You, Y. Yang, H. Gu, G. Song, N. Lu, J. Xin, Antiviral Res. 2007, 74, 16.

7)Flavonoid wogonin from medicinal herb is neuroprotective by inhibiting inflammatory activation of microglia

H. Lee, Y. O. Kim, H. Kim, S. Y. Kim, H. S. Noh, S. S. Kang, G. J. Cho, W. S. Choi, K. Suk, FASEB J. 2003, 17, 1943.


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