text.skipToContent text.skipToNavigation

Maximum quantity allowed is 999

Gelieve het aantal te selecteren

SIRT1 Inhibitor

SIRT1 is a member of the sirtuin family of enzymes that catalyze the deacetylation of acetyl-lysine residues in histones and other proteins.1) SIRT1 plays an important role in a variety of processes including stress resistance, metabolism, differentiation, and aging.1) Sirtuins are the mammalian orthologues of the yeast Sir2 (silent information regulator 2).1,2) In the catalytic process of SIRT1, NAD+ is cleaved and O-acetyl ADP-ribose is generated.1,3,4)
Ex-527 (1) is a small molecule inhibitor of SIRT1 and possesses much higher selectivity for SIRT1 than others as shown below (Table).5) 1 also does not inhibit class I/II HDACs at concentrations up to 100 μM.6)
* Class I/II HDACs are histone deacetylases and remove acetyl groups without hydrolysis of NAD+.

Table. Sirtuin inhibitory activity of Ex-5275)

Table. Sirtuin inhibitory activity of Ex-527

This product is for research purpose only.

References

The prices are subject to change without notice. Please confirm the newest price by our online catalog before placing an order.
In addition, sales products changes with areas. Please understand that a product is not available when the product details page is not displayed.