text.skipToContent text.skipToNavigation

Maximum quantity allowed is 999

Gelieve het aantal te selecteren

SingaCycle(TM)-E1 — Catalyst for the Heck-Mizoroki Reaction

* This product is not available in Canada and Americas.

A highly active, versatile and practical catalyst 1 for the Heck-Miozoroki Reaction has been developed by Ying et al. The palladium complex 1 consists of a sterically demanding N-heterocyclic carbene spectator ligand and a palladacycle as disposable part, releasing in situ the catalytically highly active mono-ligated Pd(0) species. Compound 1 is a robust and stable, ready to use catalyst which can be conveniently handled under air. 1 is available from discovery- to production scale amounts.
Typical procedure: 1a)
Aryl Bromide (1 mmol), olefin (1.2 mmol), K2CO3 (2.0 mmol) and 2 mol% NMP solution of SingaCycleTM-E1 (400 μL) are added to a vial with a magnetic stir bar. The atmosphere above the reaction mixture is purged with Ar over 30 sec. The vial is closed with a screw cap, and heated at 140 ºC with vigorous stirring over 18 h. After cooling, the reaction mixtures are filtered under dilution with CH2Cl2 (total: 20 mL). The crude product is loaded directly over a short pad of silica gel and purified by flash chromatography.

References

The prices are subject to change without notice. Please confirm the newest price by our online catalog before placing an order.
In addition, sales products changes with areas. Please understand that a product is not available when the product details page is not displayed.