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CAS RN: 63547-13-7 | Product Number: A3194

Adrafinil


Purity: >98.0%(N)
Synonyms:
  • 2-(Benzhydrylsulfinyl)-N-hydroxyacetamide
Documents:
20MG
€ 70,00
1   ≥20 
100MG
€ 202,00
1   18  
1G
€ 1.020,00
1   16  

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Product Number A3194
Purity / Analysis Method >98.0%(N)
Molecular Formula / Molecular Weight C__1__5H__1__5NO__3S = 289.35  
Physical State (20 deg.C) Solid
Storage Temperature -20°C
Condition to Avoid Heat Sensitive
CAS RN 63547-13-7
Reaxys Registry Number 1990030
PubChem Substance ID 354335694
Merck Index (14) 170
MDL Number

MFCD00865357

Specifications
Appearance White to Light yellow to Light orange powder to crystal
Purity(HPLC) min. 96.0 area%
Purity(with Total Nitrogen) min. 98.0 %
Melting point 151.0 to 154.0 °C
Properties (reference)
Melting Point 153 °C
Solubility in water Insoluble
Degree of solubility in water < 1 g/l  
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H302 : Harmful if swallowed.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
Related Laws:
EC Number 264-303-1
RTECS# AB8139500
Transport Information:
HS Number 2930909899
Application
Adrafinil: A Synthetic Psychostimulant Agent Banned by the World Anti-Doping Agency

Adrafinil is a synthetic psychostimulant agent and a prodrug of modafinil [CAS: 68693-11-8] that is a wakefulness-promoting agent used for treatment of disorders such as narcolepsy and shift work sleep disorder. The precise mechanisms of action are still unknown. Modafinil has weak to negligible interactions with receptors for norepinephrine, serotonin, dopamine, etc. Modafinil was widely believed to serve as a selective α1-adrenergic receptor agonist. Recent work, however, in vitro, modafinil binds to the dopamine transporter and inhibits dopamine reuptake. This activity has been associated in vivo with increased extracellular dopamine levels in some brain regions of animals.Adrafinil was sometimes used as a stimulatory agent in athletes, and were added to the prohibited list established by the World Anti-Doping Agency (WADA) in 28. Therefore, the effective detection of adrafinil and its metabolites in human urine has been studied. (The product is for research purpose only.)

References

Adrafinil: a novel vigilance promoting agent (a review)

N. W. Milgram, H. Callahan, C. Siwak, CNS Drug Rev. 1999, 5, 193.

Adrafinil: effects on behavior and cognition in aged canines (a review)

C. T. Siwak, H. Callahan, N. W. Milgram, Prog. Neuro-Psychopharmacol. Biol. Psychiatry 2000, 24, 709.

LC-ESI-MS determination and pharmacokinetics of adrafinil in rats

R. N. Rao, D. D. Shinde, M. V. N. K. Talluri, S. B. Agawane, J. Chromatogr. B 2008, 873, 119.

Doping control analysis for adrafinil and its major metabolites in human urine

J. Lu, X. Wang, S. Yang, X. Liu, Y. Qin, L. Shen, Y. Wu, Y. Xu, M. Wu, G. Ouyang, Rapid Commun. Mass Spectrom. 2009, 23, 1592.

Development of a validated LC method for enantiomeric separation and determination of adrafinil and its related substances on a Chiralcel OJ-H column connected to PDA and polarimetric detectors in series

R. N. Rao, P. K. Maurya, D. D. Shinde, Biomed. Chromatogr. 2010, 24, 1228.

Fluorescent zinc and copper complexes for detection of adrafinil in paper-based microfluidic devices

M. G. Caglayan, S. Sheykhi, L. Moscaa, P. Anzenbacher, Jr, Chem. Commun. 2016, 52, 8279.


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