CAS RN: 94749-08-3 | Product Number: A3190
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|Purity / Analysis Method||>98.0%(T)(HPLC)|
|Molecular Formula / Molecular Weight||C__2__5H__3__7NO__4·C__1__1H__8O__3 = 603.76|
|Physical State (20 deg.C)||Solid|
|Related CAS RN||89365-50-4|
|Reaxys Registry Number||9833043|
|PubChem Substance ID||354335558|
|Merck Index (14)||8337|
|Appearance||White to Almost white powder to crystal|
|Purity(HPLC)||min. 98.0 %(total of Ion-Pair)|
|Purity(Neutralization titration)||min. 98.0 %|
|Melting Point||138 °C(dec.)|
|Solubility in water||Insoluble|
|Solubility (soluble in)||Methanol|
|Solubility (slightly sol. in)||Ethanol|
|Solubility (insoluble in)||Diethyl ether|
Salmeterol xinafoate is a selective and long-acting β2-adrenergic receptor agonist. In vitro and in vivo studies demonstrate that salmeterol is selective for β2- adrenergic receptors compared with isoproterenol [I26], which has approximately equal agonist activity on β1 and β2- adrenergic receptors. The pharmacologic effects of β2-adrenergic receptor agonist agents, including salmeterol, attributable to stimulation of intracellular adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) [A157 (2Na salt)] to cyclic-3’,5’-adenosine monophosphate (c-AMP) [A2381, A2112 (Na salt)]. Increased c-AMP levels cause relaxation of bronchial smooth muscle and inhibition of release of inflammatory mediators from cells, especially from mast cells. The mechanism of action for long-acting is explained as follows. Salmeterol consists of a saligenin ethanolamine “head” with a large lipophilic “tail” or side chain. Because of the side chain is anchored at the exo-site, the active “head” portion continually attaches to and detaches from the receptor site. (The product is for research purpose only.)
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Determination of salmeterol in metered-dose and dry-powder inhalers by reversed-phase high performance liquid chromatography
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