CAS RN: 183232-66-8 | Product Number: A3151
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|Purity / Analysis Method||>97.0%(HPLC)|
|Molecular Formula / Molecular Weight||C__2__2H__2__1Cl__2IN__4O = 555.24|
|Physical State (20 deg.C)||Solid|
|Condition to Avoid||Heat Sensitive|
|Reaxys Registry Number||7780333|
|PubChem Substance ID||354335179|
|Appearance||White to Light yellow powder to crystal|
|Purity(HPLC)||min. 97.0 area%|
|Elemental analysis(Nitrogen)||9.60 to 10.60 %|
|Melting Point||196 °C|
|Hazard Statements||H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
|Precautionary Statements||P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P302 + P352 : IF ON SKIN: Wash with plenty of water.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P362 + P364 : Take off contaminated clothing and wash it before reuse.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
AM-251 is a cannabinoid CB1 receptors (CB1Rs) antagonist. In areas of the central nervous system (CNS), CB1 receptors have been implicated in regulation of mood and food intake. Reportedly, CB1 agonists increase food intake while CB1 receptor antagonists reduce food intake. AM-251, a CB1 receptor antagonist, have been shown to antidepressant-like and anorectic effects in rats. (The product is for research purpose only.)
Structure-Activity Relationships of Pyrazole Derivatives as Cannabinoid Receptor Antagonists
Antiobesity effects of chronic cannabinoid CB1 receptor antagonist treatment in diet-induced obese mice
Antidepressant-like and anorectic effects of the cannabinoid CB1 receptor inverse agonist AM251 in mice
Inverse agonism and neutral antagonism at cannabinoid CB1 receptors (a review)
Pharmacological actions of cannabinoids (a review)
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