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CAS RN: 41294-56-8 | Product Number: A3125

Alfacalcidol


Purity: >95.0%(HPLC)
Synonyms:
  • 1α-Hydroxyvitamin D3
  • 1α-Hydroxycholecalciferol
Documents:
10MG
€ 165,00
1   15  
50MG
€ 490,00
1   10  

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Product Number A3125
Purity / Analysis Method >95.0%(HPLC)
Molecular Formula / Molecular Weight C__2__7H__4__4O__2 = 400.65  
Physical State (20 deg.C) Solid
Storage Temperature -20°C
Store Under Inert Gas Store under inert gas
Condition to Avoid Air Sensitive,Heat Sensitive
CAS RN 41294-56-8
Reaxys Registry Number 2064794
PubChem Substance ID 354335206
Merck Index (14) 4819
MDL Number

MFCD00868328

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 95.0 area%
Melting point 134.0 to 138.0 °C
Specific rotation [a]20/D +34.0 to +38.0 deg(C=0.3, CHCL3)
Properties (reference)
Melting Point 136 °C
Specific Rotation 36° (C=0.3,CHCl3)
Maximum Absorption Wavelength 264(Diethyl ether) nm
GHS
Pictogram Pictogram
Signal Word Danger
Hazard Statements H300 + H310 + H330 : Fatal if swallowed, in contact with skin or if inhaled.
Precautionary Statements P260 : Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.
P262 : Do not get in eyes, on skin, or on clothing.
P280 : Wear protective gloves/ protective clothing.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P302 + P352 + P310 : IF ON SKIN: Wash with plenty of water. Immediately call a POISON CENTER/doctor.
P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor.
P403 + P233 : Store in a well-ventilated place. Keep container tightly closed.
Related Laws:
EC Number 255-297-1
Transport Information:
UN Number UN2811
Class 6.1
Packing Group II
HS Number 2936290000
Application
Alfacalcidol: A Prodrug of Calcitriol, the Active Form of Vitamin D3

Alfacalcidol (1α-hydroxyvitamin D3) is a prodrug of calcitriol (1α,25-dihydroxyvitamin D3) [C3078] which is the active form of vitamin D3 (cholecalciferol) [
C0314]. The natural supply of vitamin D3 in human being mainly depends on ultraviolet light for conversion of 7-dehydrocholesterol [CAS: 434-16-2] to vitamin D3 in the skin. The transformation (hydroxylation at position 25) of vitamin D3 is catalyzed by enzymes in the liver and the kidney to produce calcitriol. Calcitriol is active in the regulation of the absorption of calcium from the gastrointestinal tract.
However, alfacalcidol is rapidly hydroxylated to calcitriol in the liver, effectively bypassing the critical renal metabolic conversion. Therefore, alfacalcidol is effective for patients with chronic renal failure to remedy vitamin D3 deficiency, and to increase the bone resorption and the bone formation. (The product is for research purpose only.)

References


PubMed Literature


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