CAS RN: 41294-56-8 | Product Number: A3125
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|Purity / Analysis Method||>95.0%(HPLC)|
|Molecular Formula / Molecular Weight||C__2__7H__4__4O__2 = 400.65|
|Physical State (20 deg.C)||Solid|
|Store Under Inert Gas||Store under inert gas|
|Condition to Avoid||Air Sensitive,Heat Sensitive|
|Reaxys Registry Number||2064794|
|PubChem Substance ID||354335206|
|Merck Index (14)||4819|
|Appearance||White to Almost white powder to crystal|
|Purity(HPLC)||min. 95.0 area%|
|Melting point||134.0 to 138.0 °C|
|Specific rotation [a]20/D||+34.0 to +38.0 deg(C=0.3, CHCL3)|
|Melting Point||136 °C|
|Specific Rotation||36° (C=0.3,CHCl3)|
|Maximum Absorption Wavelength||264(Diethyl ether) nm|
|Hazard Statements||H300 + H310 + H330 : Fatal if swallowed, in contact with skin or if inhaled.
|Precautionary Statements||P260 : Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.
P262 : Do not get in eyes, on skin, or on clothing.
P280 : Wear protective gloves/ protective clothing.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P302 + P352 + P310 : IF ON SKIN: Wash with plenty of water. Immediately call a POISON CENTER/doctor.
P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor.
P403 + P233 : Store in a well-ventilated place. Keep container tightly closed.
C0314]. The natural supply of vitamin D3 in human being mainly depends on ultraviolet light for conversion of 7-dehydrocholesterol [CAS: 434-16-2] to vitamin D3 in the skin. The transformation (hydroxylation at position 25) of vitamin D3 is catalyzed by enzymes in the liver and the kidney to produce calcitriol. Calcitriol is active in the regulation of the absorption of calcium from the gastrointestinal tract.
However, alfacalcidol is rapidly hydroxylated to calcitriol in the liver, effectively bypassing the critical renal metabolic conversion. Therefore, alfacalcidol is effective for patients with chronic renal failure to remedy vitamin D3 deficiency, and to increase the bone resorption and the bone formation. (The product is for research purpose only.)
- Metabolism of 1α-hydroxyvitamin D3 to 1α,25-dihydroxyvitamin D3 in perfused rat liver
- Rate of reversal of hypercalcaemia and hypercalciuria induced by vitamin D and its 1alpha-hydroxylated derivatives.
- Alfacalcidol inhibits bone resorption and stimulates formation in an ovariectomized rat model of osteoporosis: distinct actions from estrogen
- A new look at the most successful prodrugs for active vitamin D (D hormone): alfacalcidol and doxercalciferol (a review)
- Routine isotope-dilution liquid chromatography-tandem mass spectrometry assay for simultaneous measurement of the 25-hydroxy metabolites of vitamins D2 and D3
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