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CAS RN: 137281-39-1 | Product Number: A2618

4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic Acid

Purity: >98.0%(T)(HPLC)
  • 2-Amino-4,7-dihydro-5-[2-[4-(carboxy)phenyl]ethyl]-4-oxo-3H-pyrrolo[2,3-d]pyrimidine
2   4  
≥20  12  

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Product Number A2618
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__1__5H__1__4N__4O__3 = 298.30  
Physical State (20 deg.C) Solid
CAS RN 137281-39-1
Reaxys Registry Number 6153680
PubChem Substance ID 253660028
MDL Number


Appearance White to Gray to Dark blue powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Neutralization titration) min. 98.0 %(calcd.on anh.substance)
Water 4.0 to 8.0 %
Properties (reference)
Solubility (slightly sol. in) Dimethylformamide
Pictogram Pictogram
Signal Word Warning
Hazard Statements H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
Precautionary Statements P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P302 + P352 : IF ON SKIN: Wash with plenty of water.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P362 + P364 : Take off contaminated clothing and wash it before reuse.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
Related Laws:
EC Number 429-790-9
Transport Information:
HS Number 2933599590
Syntheses of Antitumor Pemetrexed


A simple and concise synthesis of LY231514 (MTA)

E. C. Taylor, B. Liu, Tetrahedron Lett. 1999, 40, 4023.

A New and Efficient Synthesis of Pyrrolo[2,3-d]pyrimidine Anticancer Agents: Alimta (LY231514, MTA), Homo-Alimta, TNP-351, and Some Aryl 5-Substituted Pyrrolo[2,3-d]pyrimidines

E. C. Taylor, B. Liu, J. Org. Chem. 2003, 68, 9938.

A Practical Synthesis of Multitargeted Antifolate LY231514

C. J. Barnett, T. M. Wilson, M. E. Kobierski, Org. Proc. Res. Dev. 1999, 3, 184.

Determination of the Source of the N-Methyl Impurity in the Synthesis of Pemetrexed Disodium Heptahydrate

D. P. Kjell, D. W. Hallberg, J. M. Kalbfleisch, C. K. McCurry, M. J. Semo, E. M. Sheldon, J. T. Spitler, M. Wang, Org. Process Res. Dev. 2005, 9, 738.

A stability-indicating LC assay method for pemetrexed disodium

G. Saravanan, M. V. Suryanarayana, M. J. Jadhav, M. Ravikumar, N. Someswararao, P. V. R. Acharyulu, Chromatographia 2007, 66, 431.

PubMed Literature

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