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CAS RN: 138112-76-2 | Product Number: A2606

Agomelatine


Purity: >98.0%(HPLC)(N)
Synonyms:
  • N-[2-(7-Methoxy-1-naphthalenyl)ethyl]acetamide
Documents:
1G
€28.00
7   19  

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Product Number A2606
Purity / Analysis Method >98.0%(HPLC)(N)
Molecular Formula / Molecular Weight C__1__5H__1__7NO__2 = 243.31  
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Condition to Avoid Heat Sensitive
CAS RN 138112-76-2
Reaxys Registry Number 5813634
PubChem Substance ID 253661921
Merck Index (14) 190
MDL Number

MFCD00916659

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(with Total Nitrogen) min. 98.0 %
Melting point 108.0 to 112.0 °C
Properties (reference)
Melting Point 110 °C
Solubility (soluble in) Methanol
GHS
Related Laws:
RTECS# AC5956323
Transport Information:
HS Number 2924297099
Application
Agomelatine: A Melatonergic MT1 and MT2 Receptor Agonist with Serotonin 5-HT2C Receptor Antagonist Activity

Agomelatine is a melatonergic MT1 and MT2 receptor agonist with serotonin 5-HT2C receptor antagonist activity. Stimulation of melatonergic (MT1 and MT2) receptors in suprachiasmatic nucleus of hypothalamus by agomelatine leads to the restoration of disturbed circadian rhythm. Selective binding to serotonin 5HT2C receptors by agomelatine leads to an increase in norepinephrine [A0906(Bitartrate)] and dopamine [A0305(Hydrochloride)] levels.

References


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