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CAS RN: 95233-18-4 | Product Number: A2545

Atovaquone


Purity: >98.0%(T)(HPLC)
Synonyms:
  • trans-2-[4-(4-Chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthalenedione
Documents:
200MG
€34.00
4   18  
1G
€120.00
1   ≥20 

*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).


Product Number A2545
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__2__2H__1__9ClO__3 = 366.84  
Physical State (20 deg.C) Solid
Storage Temperature <0°C
Condition to Avoid Heat Sensitive
CAS RN 95233-18-4
Reaxys Registry Number 8076827
PubChem Substance ID 160871512
Merck Index (14) 866
MDL Number

MFCD00889188

Specifications
Appearance Light yellow to Brown powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Neutralization titration) min. 98.0 %
Melting point 221.0 to 225.0 °C
Properties (reference)
Melting Point 223 °C
Maximum Absorption Wavelength 494(aq. Buffer) nm
Solubility in water Insoluble
Solubility (very soluble in) Tetrahydrofuran
Solubility (slightly sol. in) Acetone
Solubility (insoluble in) Methanol
GHS
Hazard Statements H413 : May cause long lasting harmful effects to aquatic life.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P273 : Avoid release to the environment.
Related Laws:
RTECS# QJ5616500
Transport Information:
HS Number 2914790090
Application
Atovaquone: An Antifungal Reagent against Pneumocystis jiroveci

(The product is for research purpose only.)

References


Application
Studies on Antimicrobial and Antimalarial Activities of Atovaquone
References

Atovaquone, a broad spectrum antiparasitic drug, collapses mitochondrial membrane potential in a malarial parasite

I. K. Srivastava, H. Rottenberg, A. B. Vaidya, J. Biol. Chem. 1997, 272, 3961.

Resistance mutations reveal the atovaquone-binding domain of cytochrome b in malaria parasites

I. K. Srivastava, J. M. Morrisey, E. Darrouzet, F. Daldal, A. B. Vaidya, Mol. Microbiol. 1999, 33, 704.

Interactions of atovaquone with other antimalarial drugs against Plasmodium falciparum in vitro

C. J. Canfield, M. Pudney, W. E. Gutteridge, Exp. Parasitol. 1995, 80, 373.

A mechanism for the synergistic antimalarial action of atovaquone and proguanil

I. K. Srivastava, A. B. Vaidya, Antimicrob. Agents Chemother. 1999, 43, 1334.

Antiparasitic agent atovaquone

A. L. Baggish, D. R. Hill, Antimicrob. Agents Chemother. 2002, 46, 1163.


PubMed Literature


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