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CAS RN: 446-86-6 | Product Number: A2069


Purity: >98.0%(T)(HPLC)
  • 6-(1-Methyl-4-nitroimidazol-5-yl)thiopurine
€ 106,00
9   1  
€ 263,00
3   3  

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Product Number A2069
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__9H__7N__7O__2S = 277.26  
Physical State (20 deg.C) Solid
Storage Temperature <0°C
Condition to Avoid Light Sensitive,Heat Sensitive
CAS RN 446-86-6
Reaxys Registry Number 1225351
PubChem Substance ID 87559964
Merck Index (14) 902
MDL Number


Appearance Light yellow to Yellow to Green powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Neutralization titration) min. 98.0 %
Properties (reference)
Melting Point 244 °C(dec.)
Solubility in water Insoluble
Solubility (very soluble in) Chloroform,Ethanol
Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H302 : Harmful if swallowed.
H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
H350 : May cause cancer.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P201 : Obtain special instructions before use.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
Related Laws:
EC Number 207-175-4
RTECS# UO8925000
Transport Information:
HS Number 2933998090
Azathioprine: An Inhibitor of Purine Ribonucleotides and DNA/RNA Synthesis


Azathioprine, a prodrug of 6-mercaptopurine (6-MP) [M0063], was developed by Elion and Hitchings as an immunosuppressant agent for renal transplantation in 1962. They shared the Nobel Prize in 1988. In cell, 6-MP is converted to 6-thioinosine monophosphate (TIMP), catalyzed by hypoxanthine guanine phosphoribosyltransferase (HPRT). TIMP inhibits conversion of inosinic acid to adenylosuccinic acid and xanthylic acid, subsequently leading to inhibition of purine ribonucleotides and DNA/RNA synthesis. Azathioprine and 6-MP are commonly used as an immunosuppressant for treatment of rheumatism, Crohn’s disease and inflammatory bowel disease. (The product is for research purpose only.)


PubMed Literature

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