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CAS RN: 4023-02-3 | Product Number: A2055

1-Amidinopyrazole Hydrochloride


Purity: >98.0%(T)(HPLC)
Synonyms:
  • Praxadine
  • 1-Pyrazolecarboxamidine Hydrochloride
  • Pyrazole-1-carboximidamide Hydrochloride
  • 1-Carbamimidoylpyrazole Hydrochloride
Documents:
5G
€32.00
6   ≥20 
25G
€98.00
4   ≥20 

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*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).


Product Number A2055
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__4H__6N__4·HCl = 146.58  
Physical State (20 deg.C) Solid
CAS RN 4023-02-3
Reaxys Registry Number 5448758
PubChem Substance ID 87559963
MDL Number

MFCD00210087

Specifications
Appearance White to Yellow to Orange powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Melting point 165.0 to 169.0 °C
Properties (reference)
Melting Point 167 °C
GHS
Pictogram Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H302 : Harmful if swallowed.
H315 : Causes skin irritation.
H318 : Causes serious eye damage.
H373 : May cause damage to organs through prolonged or repeated exposure.
H317 : May cause an allergic skin reaction.
H412 : Harmful to aquatic life with long lasting effects.
Precautionary Statements P273 : Avoid release to the environment.
P260 : Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P314 : Get medical advice/ attention if you feel unwell.
P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor.
Related Laws:
EC Number 429-520-1
Transport Information:
HS Number 2933199090
Application
Guanidinylation

Typical Procedure:
1-Amidinopyrazole hydrochloride (1 g, 6.8 mmol) is added to a solution of 2-(benzoxazol-2-yl)ethylamine (1.1 g, 6.7 mmol) and diisopropylethylamine (4.75 mL, 27 mmol) in DMF (10 mL). The reaction mixture is stirred at room temperature under N2 for 24 h. Subsequently, diethylether (75 mL) is added, the upper layer is decanted and the remaining oil solidified by treatment with CH2Cl2. The solid is collected, washed with diethylether, CH2Cl2, and CHCl3 : i-PrOH (4 : 1) and dried to yield the product (0.86 g, Y. 52.6%).

References


PubMed Literature


TCIMAIL
Guanidinylation
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