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CAS RN: 64-19-7 | Product Number: A2035

Acetic Acid

Purity: >99.5%(T)
17   ≥20 

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Product Number A2035
Purity / Analysis Method >99.5%(T)
Molecular Formula / Molecular Weight C__2H__4O__2 = 60.05  
Physical State (20 deg.C) Liquid
Condition to Avoid Hygroscopic
CAS RN 64-19-7
Reaxys Registry Number 506007
Merck Index (14) 55
MDL Number


Appearance Colorless clear liquid
Purity(Neutralization titration) min. 99.5 %
Properties (reference)
Melting Point 17 °C
Boiling Point 118 °C
Flash point 41 °C
Specific Gravity (20/20) 1.05
Refractive Index 1.37
Maximum Absorption Wavelength 205(H2O) nm
Solubility in water Completely miscible
Solubility (miscible with) Alcohol,Benzene,Acetone,Ether
Pictogram Pictogram Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H312 : Harmful in contact with skin.
H314 : Causes severe skin burns and eye damage.
H370 : Causes damage to organs.
H226 : Flammable liquid and vapour.
H290 : May be corrosive to metals.
Precautionary Statements P260 : Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.
P210 : Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P370 + P378 : In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish.
P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor.
P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water.
P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor.
P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor.
Related Laws:
EC Number 200-580-7
RTECS# AF1225000
Transport Information:
UN Number UN2789
Class 8 / 3
Packing Group II
HS Number 2915210000
Acetylation of Alcohols using Acetylating Reagents and Acid Catalysts


1)A Simple Method for the Esterification of Carboxylic Acids Using Chlorosilanes

R. Nakao, K. Oka, T. Fukumoto, Bull. Chem. Soc. Jpn. 1981, 54, 1267.

2)A Novel Method for the Preparation of Macrolides from ω-Hydroxycarboxylic Acids

I. Shiina, T. Mukaiyama, Chem. Lett. 1994, 23, 677.

3)An Efficient Esterification Reaction between Equimolar Amounts of Free Carboxylic Acids and Alcohols by the Combined Use of

J. Izumi, I. Shiina, T. Mukaiyama, Chem. Lett. 1995, 24, 141.

4)Scandium Trifluoromethanesulfonate as an Extremely Active Lewis Acid Catalyst in Acylation of Alcohols with Acid Anhydrides and Mixed Anhydrides

K. Ishihara, M. Kubota, H. Kurihara, H. Yamamoto, J. Org. Chem. 1996, 61, 4560.

5)Protection for the Hydroxyl Group, Including 1,2- and 1,3-Diols

P. G. M. Wuts, in Greene’s Protective Groups in Organic Synthesis, 5th ed., ed. by P. G. M. Wuts, John Wiley & Sons, Inc., Hoboken, New Jersey, 2014, Chap. 2, 17.

Reagent for pain (writhing) model

Suprofen, a potent antagonist of acetic acid-induced writhing in rats

C. J. Niemegeers, J. A. Van Bruggen, P. A. Janssen, Arzneimittelforschung 1975, 25, 1505.

Acetic acid and phenylquinone writhing test: a critical study in mice

P. P. Singh, A. Y. Junnarkar, C. S. Rao, R. K. Varma, D. R. Shridhar, Methods Find. Exp. Clin. Pharmacol. 1983, 5, 601.

Effects of intrathecally administered aminoglycoside antibiotics, calcium-channel blockers, nickel and calcium on acetic acid-induced writhing test in mice

A. Doğrul, O. Yeşilyurt, Gen. Pharmacol. 1998, 30, 613.

Acetic acid induced painful endogenous infliction in writhing test on mice

S. P. Gawade, J. Pharmacol. Pharmacother. 2012, 3, 348.

Reagent for overactive bladder model

Effects of resiniferatoxin desensitization of capsaicin-sensitive afferents on detrusor over-activity induced by intravesical capsaicin, acetic acid or ATP in conscious rats

X. Zhang, Y. Igawa, O. Ishizuka, O. Nishizawa, K. E. Andersson, Naunyn Schmiedebergs Arch. Pharmacol. 2003, 367, 473.

GRC-6211, a new oral specific TRPV1 antagonist, decreases bladder overactivity and noxious bladder input in cystitis animal models

A. Charrua, C. D. Cruz, S. Narayanan, L. Gharat, S. Gullapalli, F. Cruz, A. Avelino, J. Urol. 2009, 181, 379.

Reagent for cystitis model

Effects of sodium hyaluronate on epithelial healing of the vesical mucosa and vesical fibrosis in rabbits with acetic acid induced cystitis

K. Takahashi, J. Takeuchi, T. Takahashi, S. Miyauchi, K. Horie, Y. Uchiyama, J. Urol. 2001, 166, 710.

Effects of exogenous glycosaminoglycans on the histological structure of the rat bladder in experimental cystitis

V. E. Sobolev, Bull. Exp. Biol. Med. 2012, 154, 108.

Reagent for gastric ulcer model

An overview of acetic acid ulcer models--the history and state of the art of peptic ulcer research

S. Okabe, K. Amagase, Biol. Pharm. Bull. 2005, 28, 1321.

Reagent for inflammatory bowel disease model

Experimental production of diffuse colitis in rats

B. R. MacPherson, C. J. Pfeiffer, Digestion 1978, 17, 135.

Insights from advances in research of chemically induced experimental models of human inflammatory bowel disease

M. Kawada, A. Arihiro, E. Mizoguchi, World J. Gastroenterol. 2007, 13, 5581.

Experimental colitis in animal models

H. S. Kim, A. Berstad, Scand. J. Gastroenterol. 1992, 27, 529.

PubMed Literature

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